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Peptide record

TPDB62596

KLA5 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB62596
KLA5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation
Sequence
KIAAKSIAKIWKSILKIA-NH2
Physicochemical Analysis
C95H168N24O21
RNDCEQGHMFPTYV
IK
1982.53
11.12
5
0
11
+5
0.57
0.639
152.22
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
277.42
2
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
5
I
1
L
5
K
0
M
0
F
0
P
2
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 5 L: 1 K: 5 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
18
C95H168N24O21
1982.53
11.12
+5
0.57
0.639
Amidation
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Aortic endothelial cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Probably cytoplasm and nucleus
Low relative to I (pmol internalized peptide/mg p
Non-endocytic mechanism
In vitro
CCSHHHHTTTGGGTTTTC
Additional Detail Fields 1 fields
CCSHHHHTTTGGGTTTTC