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Peptide record

TPDB62592

KH-AtOEP34 KH9- OEP34 Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB62592
KH-AtOEP34 KH9- OEP34
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
KHKHKHKHKHKHKHKHKHMFAFQYLLVM
Physicochemical Analysis
C170H262N56O31S2
RNDCEGIPSTW
HK
3650.43
11.08
18
0
9
+10
13.25
-1.632
41.79
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
40.82
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
1
Q
0
G
9
H
0
I
2
L
9
K
2
M
2
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 9 I: 0 L: 2 K: 9 M: 2 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
28
C170H262N56O31S2
3650.43
11.08
+10
13.25
-1.632
Free
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A. Thaliana Leaves

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Fusogenic
GFP-expressing plasmid DNA
Stroma Of Chloroplasts
In vitro
CCSCSCCSCSTTHHHHSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

A. Thaliana Leaves ,N. Benthamiana Leaf And Tomato (Solanum Lycopersicum (S. Lycopersicum) And Solanum Tuberosum)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Fusogenic
Cyanine‐3 (Cy3) labeled pDNA (pPpsbA::Rluc)
Cytoplasm and Chloroplasts
In vitro
CCCCCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Arabidopsis Thaliana

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
(Cy3)-labelled plasmid DNA
Chloroplast Nucleoids
cpPD-Cy3 complexes penetrate into cells and chloroplasts within 6 h after their infiltration into the extracellular space.
Endocytosis and direct penetration
In vitro
CCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Tobacco (Nicotiana Tabacum), Rice (Oryza Sativa) And Kenaf (Hibiscus Cannabinus)

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Fusogenic
Plasmid DNA
Plastids
Genotyping PCR of tobacco and rice showed amplification of products that corresponded to the size of the predicted products from the integrated ptDNA.
In vitro
Additional Detail Fields 1 fields
CCSCSCCSCSTTHHHHSCC CCCCCCCC CCCCC