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Peptide record

TPDB62590

(KH)9 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB62590
(KH)9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Nanoparticle
Sequence
KHKHKHKHKHKHKHKHKH-NH2
Physicochemical Analysis
C108H173N45O19
ARNDCEQGILMFPSTWYV
HK
2405.85
11.41
18
0
0
+10
17.55
-3.550
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
9
H
0
I
0
L
9
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 9 I: 0 L: 0 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C108H173N45O19
2405.85
11.41
+10
17.55
-3.550
Amidation
Nanoparticle
L
Cationic
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells And Fibroblast Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FITC-labeled pDNA (pCAG-GFP-ND)
Cytosol
Exhibiting slightly higher fluorescence levels relative to WRAP1/pND1 particles
In vitro
CCTTHHHHTTTTTTC
Additional Detail Fields 1 fields
CCTTHHHHTTTTTTC