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Peptide record

TPDB62581

DPA-R8-FL Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62581
DPA-R8-FL
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: 2,2′-dipicolylamine moiety (DPA)–metal complexes at Lyseine N-terminal: Acetylation
Sequence
Ac-KGRRRRRRRRGC-NH2
Physicochemical Analysis
C61H121N37O13S1
ANDEQHILMFPSTWYV
R
1612.93
12.88
9
0
0
+9
7.25
-3.183
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
8
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C61H121N37O13S1
1612.93
12.88
+9
7.25
-3.183
Amidation
2,2′-dipicolylamine moiety (DPA)–metal complexes at Lyseine
L
Cationic
Linear
Acetylation
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
5–(iodoacetamido)fluorescein and FTase inhibitor, FTI277 at cysteine at C terminus
Cytosol
Cellular uptake of DPA-R8-FL in the presence of Ni(II), Co(II), and Zn(II) was 5.3, 3.6 and 1.7 times higher than in the absence of metals.
Direct translocation
In vitro and ex vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC