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Peptide record

TPDB62580

CL Peptide Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62580
CL Peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Gly-Gly linker or a Lys(acetyl)-Gly linker
Sequence
KGRLLRLLRRRRRRRR
Physicochemical Analysis
C92H181N47O17
ANDCEQHIMFPSTWYV
R
2217.75
13.36
11
0
4
+11
6.86
-2.131
97.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
4
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C92H181N47O17
2217.75
13.36
+11
6.86
-2.131
Free
Gly-Gly linker or a Lys(acetyl)-Gly linker
L
Cationic
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDCKII cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
5FAM, 6TAMRA, and IR800CW
Higher cell uptake of CL-cargo than Arg9- and TP2-cargo conjugates
Direct translocation and endocytosis
In vitro
CCCCCCCSSTHHHHTTC
Additional Detail Fields 1 fields
CCCCCCCSSTHHHHTTC