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Peptide record

TPDB62571

Chimeric-Ovo Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62571
Chimeric-Ovo
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acylation
Sequence
KFSQRKKHMKRHTRVH-NH2
Physicochemical Analysis
C91H154N36O20S1
ANDCEGILPWY
K
2104.51
12.72
10
0
3
+7
8.83
-2.175
18.12
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
3
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
1
Q
0
G
3
H
0
I
0
L
4
K
1
M
1
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 3 I: 0 L: 0 K: 4 M: 1 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
16
C91H154N36O20S1
2104.51
12.72
+7
8.83
-2.175
Amidation
L
Cationic
Linear
Acylation
N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U373MG cells

Assay & Model

Schmidtea mediterranea (planaria)
Schmidtea mediterranea (planaria)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
6-carboxytetramethylrhodamine (TAMRA) dye
Translocation efficacy of 0.76 ± 0.08
In vitro and in vivo
CCSCCSTHIIIIITTTTTGGGTSSSCC
Additional Detail Fields 1 fields
CCSCCSTHIIIIITTTTTGGGTSSSCC