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Peptide record

TPDB62553

FITC-WT1-pTj Cell-penetrating Peptides standard
28 amino acids
Basic Information
3D PDB MODEL
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TPDB62553
FITC-WT1-pTj
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 28-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Sequence
KDCERRFSRSDQLKRHQRRHTGVKPFQK
Physicochemical Analysis
C149H247N57O41S1
ANIMWY
R
3525.02
11.80
12
3
4
+7
14.83
-2.079
24.29
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
7
Residue Composition
number
0
A
6
R
0
N
2
D
1
C
1
E
3
Q
1
G
2
H
0
I
1
L
4
K
0
M
2
F
1
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 2 C: 1 E: 1 Q: 3 G: 1 H: 2 I: 0 L: 1 K: 4 M: 0 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
28
C149H247N57O41S1
3525.02
11.80
+7
14.83
-2.079
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A2058 human melanoma cells, B16F10-Nex2 syngeneic murine melanoma, HFF and MEF cells-- A2058 and SK-MEL-28, MCF-7 and MDA-MB231, OVCAR-3 and HL-62

Assay & Model

Six-to-eight week-old, C57BL / syngeneic mice
Six-to-eight week-old, C57BL / syngeneic mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (FITC)
Cytoplasm and nucleus
Higher uptake efficency
In vitro and in vivo
CCCSSCCCSHHHHHSCCSSCCCCCCC
Additional Detail Fields 1 fields
CCCSSCCCSHHHHHSCCSSCCCCCCC