TPDB

3D PDB MODEL

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TPDB ID TPDB62551

Peptide_Name

DLCC-1 DLCC-2

Activity

Cell-penetrating Peptides

Activity_category_statistics

Delivery and barrier-penetrating peptides

Database_Source

CPPsite3.0

Sequence_Type

standard

Has_Modification No

Description A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.

Sequence

KCSSKKSKHCG

FASTA

>TPDB62551|Cell-penetrating Peptides|length=11
KCSSKKSKHCG

Formula C47H85N17O15S2

Absent Amino Acids ARNDEQILMFPTWYV

Common Amino Acids K

Mass 1192.42

PI 10.17

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 0

Net Charge +4

Boman Index 4.84

Hydrophobicity -1.509

Aliphatic Index 0.00

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 125

Absorbance 280nm 10.48

Polar Residues 5

number

0

A

0

R

0

N

0

D

2

C

0

E

0

Q

1

G

1

H

0

I

0

L

4

K

0

M

0

F

0

P

3

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 3 T: 0 W: 0 Y: 0 V: 0

Length

11

Formula

C47H85N17O15S2

Mass

1192.42

PI

10.17

Net Charge

+4

Boman Index

4.84

Hydrophobicity

-1.509

C_terminal_Modification

Free

Chirality

L

Ionic_State

Cationic

Linearity

Cyclic

N_terminal_Modification

Free

SMILES

N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O

Evidence 1 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Abdominal Skin From Male Kunming (Km) Mice

Assay & Model

In Vitro Model Male Kunming (KM) mice

In Vivo Model Male Kunming (KM) mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

Source Activity Label	Source Definition
Cell-penetrating Peptides	CPPsite3.0 experimentally validated cell-penetrating peptide annotation.

CPP Category Natural residues Cyclic L Cationic

Source of Peptide Synthetic

Cargo Type Triptolide (TP)

Uptake Efficiency No change in accumulative penetration amount of TP

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CCCSSSTTCCCTTTTC

Evidence 2 Activity

Activity

Detail Source Activity Cell-penetrating Peptides

Target

Cell Line Abdominal Skin From Male Kunming (Km) Mice

Assay & Model

In Vitro Model Male Kunming (KM) mice

In Vivo Model Male Kunming (KM) mice

Source & Reference

Database Source CPPsite3.0

Source CPPsite3

Other

CPP Category Natural residues Cyclic L Cationic

Source of Peptide Synthetic

Cargo Type Triptolide (TP)

Uptake Efficiency Accumulative penetration amount of TP increased 1.71-fold better than TD-34

In Vitro or In Vivo In vitro and in vivo

DSSP Secondary Structure CTTHHHHHHHSSCSCCCCCC

DSSP_Secondary_Structure

CCCSSSTTCCCTTTTC CTTHHHHHHHSSCSCCCCCC