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Peptide record

TPDB62545

M2 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62545
M2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
KCFQWQRNMRKVRGPPVSSIKR-NH2
Physicochemical Analysis
C118H197N41O28S2
ADEHLTY
R
2702.24
12.42
7
0
6
+7
5.34
-1.191
44.09
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
203.53
6
Residue Composition
number
0
A
4
R
1
N
0
D
1
C
0
E
2
Q
1
G
0
H
1
I
0
L
3
K
1
M
1
F
2
P
2
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 1 H: 0 I: 1 L: 0 K: 3 M: 1 F: 1 P: 2 S: 2 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
22
C118H197N41O28S2
2702.24
12.42
+7
5.34
-1.191
Amidation
L
Linear
Conjugation with fluorescein
N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
Vesicles at low concentartion and cytoplasm and nucleus at high concentart
Lower than hLF peptide
In vitro
CCCCTHHHHTTTCCCCCCSCCC
Additional Detail Fields 1 fields
CCCCTHHHHTTTCCCCCCSCCC