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Peptide record

TPDB62540

hLF-v2 Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62540
hLF-v2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Nanoparticle
Sequence
KCFQWLKNLKKVKALLVSCLKK-NH2
Physicochemical Analysis
C123H212N32O26S2
RDEGHIMPTY
K
2619.36
10.65
7
0
10
+7
1.77
0.045
119.55
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5625
214.75
5
Residue Composition
number
1
A
0
R
1
N
0
D
2
C
0
E
1
Q
0
G
0
H
0
I
5
L
7
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 5 K: 7 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
22
C123H212N32O26S2
2619.36
10.65
+7
1.77
0.045
Amidation
Nanoparticle
L
Amphipathic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mc3T3 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
(Cy5)-labeled Luciferase mRNA
Cytosol
Luciferase activity was even lower than naked mRNA, indicating that complexation with variant hLF-v2 shielded the mRNA from uptake and intracellular delivery.
In vitro
CTHHHHHHHHHHHHIIIIIICC
Additional Detail Fields 1 fields
CTHHHHHHHHHHHHIIIIIICC