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Peptide record

TPDB62539

rLF Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62539
rLF
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Conjugation with fluorescein
Sequence
KCFMWQEMLNKAGVPKLRCARK-NH2
Physicochemical Analysis
C116H193N35O27S4
DHISTY
K
2638.27
10.55
6
1
9
+5
3.75
-0.500
57.73
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5625
213.21
4
Residue Composition
number
2
A
2
R
1
N
0
D
2
C
1
E
1
Q
1
G
0
H
0
I
2
L
4
K
2
M
1
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 0 C: 2 E: 1 Q: 1 G: 1 H: 0 I: 0 L: 2 K: 4 M: 2 F: 1 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C116H193N35O27S4
2638.27
10.55
+5
3.75
-0.500
Amidation
L
Linear
Conjugation with fluorescein
N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa and IEC-6 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (fluorescein)
Vesicles
Very less uptake was observed
In vitro
CCCCTHHHHSSSSSCCCCCCCC
Additional Detail Fields 1 fields
CCCCTHHHHSSSSSCCCCCCCC