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Peptide record

TPDB62536

P7 (SmacN7–Arg8) Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB62536
P7 (SmacN7–Arg8)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: SmacN7
Sequence
KAVPIAQKEGGKRRRRRRRR-NH2
Physicochemical Analysis
C102H192N48O24
NDCHLMFSTWY
R
2474.95
12.88
11
1
4
+10
11.94
-2.240
44.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
8
R
0
N
0
D
0
C
1
E
1
Q
2
G
0
H
1
I
0
L
3
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 8 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 2 H: 0 I: 1 L: 0 K: 3 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
20
C102H192N48O24
2474.95
12.88
+10
11.94
-2.240
Amidation
SmacN7
L
Bicyclic
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U266 Mm Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Bicyclic L
Chimeric
FITC at N terminal via Ahx linker
P7 uptake is higher than the other compact bicyclic peptide (P6)
In vitro