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Peptide record

TPDB62524

ZicA2 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62524
ZicA2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Acylation
Sequence
KAFKAKYKLVNHIRVH-NH2
Physicochemical Analysis
C92H150N28O19
DCEQGMPSTW
K
1952.38
11.04
7
0
8
+5
3.97
-0.512
97.50
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
76.32
2
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
2
H
1
I
1
L
4
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 1 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
16
C92H150N28O19
1952.38
11.04
+5
3.97
-0.512
Amidation
L
Cationic
Linear
Acylation
N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U373MG cells

Assay & Model

Schmidtea mediterranea (planaria)
Schmidtea mediterranea (planaria)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
6-carboxytetramethylrhodamine (TAMRA) dye
Translocation efficacy of 0.34 ± 0.02
In vitro and in vivo
CCSCSCSSSCCTTTHHHHSCCCCCC
Additional Detail Fields 1 fields
CCSCSCSSSCCTTTHHHHSCCCCCC