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Peptide record

TPDB62523

KAFAK Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB62523
KAFAK
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
Sequence
KAFAKLAARLYRKALARQLGVAA
Physicochemical Analysis
C114H196N36O26
NDCEHIMPSTW
A
2487.04
12.15
6
0
15
+6
0.39
0.270
115.22
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
1490
59.91
2
Residue Composition
number
8
A
3
R
0
N
0
D
0
C
0
E
1
Q
1
G
0
H
0
I
4
L
3
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 8 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 4 K: 3 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
23
C114H196N36O26
2487.04
12.15
+6
0.39
0.270
Free
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

THP-1 and ex vivi bovine knee cartilage tisssue

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
in vitro and ex vivo
CTTHHHHHHHHHHHHHHHTCCCC
Additional Detail Fields 1 fields
CTTHHHHHHHHHHHHHHHTCCCC