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Peptide record

TPDB62522

κFGF-MTS Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62522
κFGF-MTS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Fluorescein-labelled
Sequence
KAAVALLPAVLLALLP
Physicochemical Analysis
C77H137N17O17
RNDCEQGHIMFSTWY
L
1573.04
10.10
1
0
13
+1
-2.18
2.069
213.75
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
5
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
1
K
0
M
0
F
2
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 5 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 1 M: 0 F: 0 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
16
C77H137N17O17
1573.04
10.10
+1
-2.18
2.069
Free
Fluorescein-labelled
L
Hydrophobic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat T Clone E6-1, H9 T Cells, PBMCs And MAGI-CCR5

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
anti-p24 mAb and Fluorescein dye
Cytosol
κFGF-MTS conjugated anti-p24 mAb showed maximum internalization in both Jurkat or H9 T cell
In vitro
CCCTTHHHHHHHTTCC
Additional Detail Fields 1 fields
CCCTTHHHHHHHTTCC