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Peptide record

TPDB62518

P7-5 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB62518
P7-5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Sequence
IYLATALAKWALKQGFGGRRRRRRR
Physicochemical Analysis
C134H226N50O29
NDCEHMPSV
R
3001.59
12.80
9
0
11
+9
1.81
-0.840
78.40
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
6990
232.88
3
Residue Composition
number
4
A
7
R
0
N
0
D
0
C
0
E
1
Q
3
G
0
H
1
I
3
L
2
K
0
M
1
F
0
P
0
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 3 K: 2 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
25
C134H226N50O29
3001.59
12.80
+9
1.81
-0.840
Free
L
Cationic
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat and CHO

Assay & Model

Male white rats
Male white rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Fluorophore [DiSC3(5)] and peptide P7-27
Mitochondria
In vitro and in vivo
CCSIIIIIHHHHTTSGGGCCTTCCC
Additional Detail Fields 1 fields
CCSIIIIIHHHHTTSGGGCCTTCCC