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Peptide record

TPDB62512

A13E/L17E Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB62512
A13E/L17E
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
IWLTALKFLGKHEAKHEAKQQLSKL-NH2
Physicochemical Analysis
C136H221N37O34
RNDCMPYV
LK
2918.48
10.38
7
2
11
+3
5.75
-0.440
105.60
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
188.45
4
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
2
E
2
Q
1
G
2
H
1
I
5
L
5
K
0
M
1
F
0
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 2 G: 1 H: 2 I: 1 L: 5 K: 5 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C136H221N37O34
2918.48
10.38
+3
5.75
-0.440
Amidation
L
Cationic and amphiphilic
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphiphilic
Synthetic
Dextran labelled with Alexa Fluor 488
Cytoplasm and nucleus
∼15% of cells treated with A13E/L17E yielded cytosolic/nuclear localization of Alexa488–dextran signals
In vitro
CCTTTSCSSCCSSSCHHHHTTCC
Additional Detail Fields 1 fields
CCTTTSCSSCCSSSCHHHHTTCC