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Peptide record

TPDB62511

L17Aad Cell-penetrating Peptides modified_plain modified
25 amino acids
Basic Information
3D PDB MODEL
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TPDB62511
L17Aad
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 25-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: X = L-2-aminoadipic acid
Sequence
IWLTALKFLGKHAAKHXAKQQLSKL-NH2
Physicochemical Analysis
C129H212N36O29
RNDCEMPYV
LK
2731.33
11.12
7
0
12
+5
1.54
-0.088
109.60
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
201.37
4
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
2
Q
1
G
2
H
1
I
5
L
5
K
0
M
1
F
0
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 2 I: 1 L: 5 K: 5 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C129H212N36O29
2731.33
11.12
+5
1.54
-0.088
Amidation
X = L-2-aminoadipic acid
Modified
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Nih3T3 And Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified
Synthetic
Alexa Fluor 488-labelled Dex12
Cytoplasm
15 % higher than L17E
Endocytosis
In vitro