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Peptide record

TPDB62508

L17EΔ(23–25) Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62508
L17EΔ(23–25)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
IWLTALKFLGKHAAKHEAKQQL-NH2
Physicochemical Analysis
C119H191N33O28
RNDCMPSYV
ALK
2532.03
10.55
6
1
11
+3
3.00
-0.218
106.82
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
217.22
3
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
1
E
2
Q
1
G
2
H
1
I
4
L
4
K
0
M
1
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 2 G: 1 H: 2 I: 1 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
22
C119H191N33O28
2532.03
10.55
+3
3.00
-0.218
Amidation
L
Cationic and amphiphilic
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and amphiphilic
Synthetic
Dextran labelled with Alexa Fluor 488
Cytosol
Yielded a diffuse cytosolic distribution of dextran in 15% of cells
In vitro
CCSTTHHHHTSSSSSHHHHHTTC
Additional Detail Fields 1 fields
CCSTTHHHHTSSSSSHHHHHTTC