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Peptide record

TPDB62503

HA/E2 Cell-penetrating Peptides standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB62503
HA/E2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 25-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
IWLTALKFLGKAAAKAEAKQELSKL-NH2
Physicochemical Analysis
C128H214N32O33
RNDCHMPYV
A
2729.30
10.38
5
2
14
+3
2.74
0.172
117.60
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
201.52
3
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
2
E
1
Q
1
G
0
H
1
I
5
L
5
K
0
M
1
F
0
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 2 Q: 1 G: 1 H: 0 I: 1 L: 5 K: 5 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
25
C128H214N32O33
2729.30
10.38
+3
2.74
0.172
Amidation
L
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Nih3T3 And Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Alexa Fluor 488-labelled Dex15
Cytoplasm
Cytosolic Dex10-Alexa signal in ≈70 % of cells
Endocytosis
In vitro
CCSTTHHHHTSSSSSHHHHHTTC
Additional Detail Fields 1 fields
CCSTTHHHHTSSSSSHHHHHTTC