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Peptide record

TPDB62501

Conjugate 22[L17E(2.7)-GFP11(2.7)-dextran-TAMRA] Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62501
Conjugate 22[L17E(2.7)-GFP11(2.7)-dextran-TAMRA]
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with Propargyl Glycine Chemical: Dextran polymer
Sequence
IWLTALKFLGHAAKHEAKQQLSKL
Physicochemical Analysis
C128H207N35O31
RNDCMPYV
L
2732.27
10.55
6
1
12
+3
2.57
-0.075
114.17
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
201.30
4
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
1
E
2
Q
1
G
2
H
1
I
5
L
4
K
0
M
1
F
0
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 2 G: 1 H: 2 I: 1 L: 5 K: 4 M: 0 F: 1 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
24
C128H207N35O31
2732.27
10.55
+3
2.57
-0.075
Conjugated with Propargyl Glycine
Dextran polymer
L
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells (Expressing Gfp 1–10)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
TAMRA-labelled and GFP 11
Cytosol
HeLa-GFP 1–10 cells treated with Conjugate 22 displayed distinctly higher GFP-fluorescence in a concentration-dependent manner than dextran hybrid 23.
In vitro
CCCHHHHTTSSSCSGGGTTTCC
Additional Detail Fields 1 fields
CCCHHHHTTSSSCSGGGTTTCC