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Peptide record

TPDB62487

NYAD-41 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB62487
NYAD-41
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Chemical: S5 [(S)-2-(4′-pentenyl)alanine] and R8 [(R)-2-(7′-octenyl)alanine] indicate stapling sites in the peptide sequence. N-terminal: Acetylation
Sequence
Ac-ISFDELLDYYGESGS
Physicochemical Analysis
C76H107N15O29
ARNCQHKMPTWV
S
1694.77
2.83
0
4
6
-4
2.47
-0.327
78.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
2980
175.84
5
Residue Composition
number
0
A
0
R
0
N
2
D
0
C
2
E
0
Q
2
G
0
H
1
I
2
L
0
K
0
M
1
F
0
P
3
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 2 C: 0 E: 2 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 0 M: 0 F: 1 P: 0 S: 3 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
15
C76H107N15O29
1694.77
2.83
-4
2.47
-0.327
Free
S5 [(S)-2-(4′-pentenyl)alanine] and R8 [(R)-2-(7′-octenyl)alanine] indicate stapling sites in the peptide sequence.
L
Linear
Acetylation
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MT-2 cells, TZM-bl cells (a HeLa cell line derivative),HEK 293T cells, primary human cells, Jurkat

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FAM)
In vitro
CCSGGGTTTTSCSCC
Additional Detail Fields 1 fields
CCSGGGTTTTSCSCC