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Peptide record

TPDB62461

IL15.3 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB62461
IL15.3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
IKHWKKVWKHAKKVL
Physicochemical Analysis
C95H153N27O16
RNDCEQGMFPSTY
K
1929.43
11.21
8
0
7
+6
3.26
-0.873
97.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
11000
570.12
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
1
I
1
L
6
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 1 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 2
Chemical Descriptors
15
C95H153N27O16
1929.43
11.21
+6
3.26
-0.873
Free
L
Hydrophobic
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PBMC, Vero Cells, Hacat Cells, And 3T3-L1 Cells

Assay & Model

Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 27736), Pseudomonas aeruginosa (ATCC 27853), Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 25923) and Staphylococcus epidermidis
Escherichia coli (ATCC 25922), Klebsiella pneumoniae (ATCC 27736), Pseudomonas aeruginosa (ATCC 27853), Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 25923) and Staphylococcus epidermidis

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Hydrophobic
Synthetic
FITC-conjugated
Cytosol
On human cells, the FITC-labelled IL15.3 shows only 0.9 to 4.9% of the FITC signal, showing poor uptake by this cell. While E. coli cells with FITC-labelled IL15.3 showed significantly more signal above the FITC threshold (78.7 to 98.4% for E. coli ), suggesting more penetration to microbes.
Membrane damage
In vitro and in vivo
CCSHHHHSSCCCC
Additional Detail Fields 1 fields
CCSHHHHSSCCCC