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Peptide record

TPDB62458

Xentry peptides Cell-penetrating Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB62458
Xentry peptides
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia
standard
No
A 4-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0 and Peptipedia, with an available 3D structural model.
Sequence
IIIR
Physicochemical Analysis
C24H47N7O5
ANDCEQGHLKMFPSTWYV
I
513.68
11.05
1
0
3
+1
-0.12
2.250
292.50
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C24H47N7O5
513.68
11.05
+1
-0.12
2.250
Free
L
Linear
Free
N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HepG2, WM-266-4 and BT549

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Fluorophore (FITC- and TAMRA)
Cytoplasm
Improved Uptake efficiency
Probably Clathrin mediated endocytosis and is dependent on HSPG-decorated syndecan-4
In vitro
CCCC
Additional Detail Fields 1 fields
CCCC