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Peptide record

TPDB62455

IR15 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB62455
IR15
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
ICSSHYEPTVRIGGR
Physicochemical Analysis
C71H115N23O22S1
ANDQLKMFW
RGIS
1674.90
8.91
3
1
4
+1
3.74
-0.400
71.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
1490
88.96
5
Residue Composition
number
0
A
2
R
0
N
0
D
1
C
1
E
0
Q
2
G
1
H
2
I
0
L
0
K
0
M
0
F
1
P
2
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 2 H: 1 I: 2 L: 0 K: 0 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
15
C71H115N23O22S1
1674.90
8.91
+1
3.74
-0.400
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa And Hacat Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
FITC dye and Imatinib Mesylate
Cytoplasm (More) And Nucleus (Less)
Time and concentration-dependent internalization higher than SR11
Lipid-raft mediated endocytosis
In vitro
CCGGGTSCC
Additional Detail Fields 1 fields
CCGGGTSCC