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Peptide record

TPDB62443

Secretin Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB62443
Secretin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
HSDGTFTSELSRLLREGARLQRLQGLV-NH2
Physicochemical Analysis
C130H219N43O41
NCIKMPWY
L
3040.43
10.73
5
3
9
+1
6.74
-0.448
101.11
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
7
Residue Composition
number
1
A
4
R
0
N
1
D
0
C
2
E
2
Q
3
G
1
H
0
I
6
L
0
K
0
M
1
F
0
P
3
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 1 C: 0 E: 2 Q: 2 G: 3 H: 1 I: 0 L: 6 K: 0 M: 0 F: 1 P: 0 S: 3 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
27
C130H219N43O41
3040.43
10.73
+1
6.74
-0.448
Amidation
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
FITC labelled
Levels of internalization of secretin were around 50% of that observed for the TAT (48–60) peptide
In vitro
CCCCCCCTTSSCSCCCCSSCCSSCC
Additional Detail Fields 1 fields
CCCCCCCTTSSCSCCCCSSCCSSCC