Back to search

Peptide record

TPDB62442

VIP-TAT Cell-penetrating Peptides standard
39 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62442
VIP-TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia
standard
No
A 39-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, and Peptipedia, with an available 3D structural model.
N-terminal: Conjugated with VIP
Sequence
HSDAVFTDNYTALRKQMAVKKYLNSILNYGRKKRRQRRR
Physicochemical Analysis
C208H346N72O56S1
CEPW
R
4783.54
11.77
13
2
14
+10
10.47
-1.323
62.56
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
4470
93.45
12
Residue Composition
number
3
A
7
R
3
N
2
D
0
C
0
E
2
Q
1
G
1
H
1
I
3
L
5
K
1
M
1
F
0
P
2
S
2
T
0
W
3
Y
2
V
Amino Acid Distribution
A: 3 R: 7 N: 3 D: 2 C: 0 E: 0 Q: 2 G: 1 H: 1 I: 1 L: 3 K: 5 M: 1 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 3 V: 2
Chemical Descriptors
39
C208H346N72O56S1
4783.54
11.77
+10
10.47
-1.323
Free
L
Cationic
Linear
Conjugated with VIP
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Neuro2a cells

Assay & Model

Male NIH mice
Male NIH mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (FITC)
Higher uptake efficiency
In vitro and in vivo
CCSSSTTSTTGGGHHHHHHHHIIIIITCSSCTTSCCCC
Additional Detail Fields 1 fields
CCSSSTTSTTGGGHHHHHHHHIIIIITCSSCTTSCCCC