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Peptide record

TPDB62438

linear (HR)3 Cell-penetrating Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB62438
linear (HR)3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 6-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Arachidic acid (C20)
Sequence
HRHRHR
Physicochemical Analysis
C36H59N21O7
ANDCEQGILKMFPSTWYV
RH
898.00
12.70
6
0
0
+3
5.31
-3.850
0.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C36H59N21O7
898.00
12.70
+3
5.31
-3.850
Free
Arachidic acid (C20)
L
Cationic
Linear
Free
N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
CF-labelled GpYEEI
Both C20-(HR)4 and C20-(HR)3 fatty acy peptides increased the cellular uptake of phosphopeptide by about 4.8 and 4.5 times, respectively, as compared to the free CF-GpYEEI.
In vitro
CC
Additional Detail Fields 1 fields
CC