Back to search

Peptide record

TPDB62429

Tet-1 G23 Blood-Brain Barrier Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62429
Tet-1 G23
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
HLNILSTLWKYR
Physicochemical Analysis
C73H114N20O17
ADCEQGMFPV
L
1543.83
10.42
3
0
6
+2
-1.33
-0.242
130.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
6990
452.77
4
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
3
L
1
K
0
M
0
F
0
P
1
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 1 M: 0 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
12
C73H114N20O17
1543.83
10.42
+2
-1.33
-0.242
Free
L
Linear
Cationic
Linear
Free
Similarity
HisLeuAsnIleLeuSerThrLeuTrpLysTyrArg
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 5 records
Evidence 1 Activity

Activity

Blood-Brain Barrier

Target

hCMEC/D3

Assay & Model

Fluoroscent measure
G23 peptide can cross basal layer
Origin/Source

Source & Reference

NA
B3Pdb

Other

Phage display of prion proteins
Transcytosis as well as BBB penetration
Evidence 2 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
Radioimaging
0.052 + 0.019 of fluoroscent measured in btain tissue after 4 hours

Source & Reference

NA
B3Pdb

Other

Phage display of prion proteins
Intravenous
Transcytosis as well as BBB penetration
Evidence 3 Activity

Activity

Blood-Brain Barrier

Assay & Model

Origin/Source
Radioimaging
0.047 + 0.031 of fluoroscent measured in btain tissue after 24 hours

Source & Reference

NA
B3Pdb

Other

Phage display of prion proteins
Intravenous
Transcytosis as well as BBB penetration
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

HET-CAM (hen’s egg–CHOrioallantoic membrane)

Assay & Model

Adult male albino New Zealand rabbits ( 2.5 kg)
Adult male albino New Zealand rabbits ( 2.5 kg)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
PLGA nanoparticles loaded Licochalcone-A
In vitro and in vivo
CCCGGGGGTTGGGGCCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 and RAW 264.7 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
Licochalcone-A (Lico-A) PLGA NPs
In vitro
CCCCCCCCCCCCC
Additional Detail Fields 2 fields
CCCGGGGGTTGGGGCCCC CCCCCCCCCCCCC
Intravenous