Back to search

Peptide record

TPDB62427

PF131 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62427
PF131
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation N-terminal: Stearylation
Sequence
HLHHLLKINLKALAALAKKIL-NH2
Physicochemical Analysis
C112H196N32O23
RDCEQGMFPSTWYV
L
2358.99
11.00
7
0
13
+4
2.04
0.671
186.19
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
4
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
3
H
2
I
7
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 2 L: 7 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C112H196N32O23
2358.99
11.00
+4
2.04
0.671
Amidation
L
Amphipathic
Linear
Stearylation
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Pluc 705 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Splice correcting oligonucleotide (PS-20-OMe SCO)
Fold increase in activity over treatment with oligonucleotide alone.
In vitro
CCTTSCHHHHTTTGGGTC
Additional Detail Fields 1 fields
CCTTSCHHHHTTTGGGTC