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Peptide record

TPDB62426

P4 Cell-penetrating Peptides modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62426
P4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
modified_plain
Yes
A 14-aa modified cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Modified, details unspecified
Sequence
HKKKKQBKKKHRWP
Physicochemical Analysis
C81H137N29O15
ANDCEGILMFSTYV
K
1757.16
11.93
10
0
1
+8
8.84
-3.157
0.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5500
313.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
2
H
0
I
0
L
7
K
0
M
0
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 2 I: 0 L: 0 K: 7 M: 0 F: 0 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C81H137N29O15
1757.16
11.93
+8
8.84
-3.157
Free
Modified
Cationic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa 654 Cells

Source & Reference

CPPsite3.0
CPPsite3
WO2020028254A1, WO2019178479A1, WO2019079386A1,WO2019079367A0

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear Modified Cationic
Synthetic
PMO anti-IVS2-658
Cytosol and Nucleus
In vitro