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Peptide record

TPDB62423

DNA-IL-PEI Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62423
DNA-IL-PEI
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Conjugation with PEI N-terminal: Conjugation with DNA
Sequence
HILPWKWPWWPWRR
Physicochemical Analysis
C106H138N28O15
ANDCEQGMFSTYV
W
2044.44
12.41
4
0
7
+3
-5.20
-1.221
55.71
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
27500
1345.11
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
1
L
1
K
0
M
0
F
3
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 1 M: 0 F: 0 P: 3 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
14
C106H138N28O15
2044.44
12.41
+3
-5.20
-1.221
Conjugation with PEI
L
Cationic
Linear
Conjugation with DNA
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human embryonic kidney cell line (HEK-293T) and NIH 3T3 fibroblasts

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nucleic acid (DNA), PEI
Higher uptake efficiency
In vitro
CCCCCCSSSSSCC
Additional Detail Fields 1 fields
CCCCCCSSSSSCC