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Peptide record

TPDB62417

STR-KV Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62417
STR-KV
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Stearylation
Sequence
HHHKKKVVVVVV
Physicochemical Analysis
C66H113N21O13
ARNDCEQGILMFPSTWY
V
1408.76
10.84
6
0
6
+3
6.27
0.325
145.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
3
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
6
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 6
Chemical Descriptors
12
C66H113N21O13
1408.76
10.84
+3
6.27
0.325
Free
L
Amphiphilic
Linear
Stearylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549, CHO-K1 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphiphilic
Synthetic
Cy3-labeled GAPDH siRNA
Around the Nucleus
Co-incubating with the HSPG analogue heparin decreased uptake of STR-KV/siRNA complexes, which implies that heparin hinders transfection of STR-KV/siRNA complexes.
Direct translocation
In vitro