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Peptide record

TPDB62407

6His-CM18-PTD4 Cell-penetrating Peptides standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB62407
6His-CM18-PTD4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 35-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
HHHHHHKWKLFKKIGAVLKVLTTGYARAAARQARA
Physicochemical Analysis
C185H293N63O40
NDCEMPS
A
4039.76
12.17
14
0
16
+9
7.06
-0.583
81.14
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
6990
173.03
4
Residue Composition
number
7
A
3
R
0
N
0
D
0
C
0
E
1
Q
2
G
6
H
1
I
3
L
5
K
0
M
1
F
0
P
0
S
2
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 7 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 6 I: 1 L: 3 K: 5 M: 0 F: 1 P: 0 S: 0 T: 2 W: 1 Y: 1 V: 2
Chemical Descriptors
35
C185H293N63O40
4039.76
12.17
+9
7.06
-0.583
Free
L
Amphiphilic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, Hek293T, THP-1, Jurkat, CHO, Nih3T3, Ca46, Balb3T3, Ht2, Kms-12, Dohh2, Rec-1, Hcc 78, Nk Cells, And Nci-H196 Cells And Cortical Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphiphilic
Synthetic
GFP-NLS ,HoxB4 transcription factor , Cas9/Cpf1 ribonucleoprotein (RNP)
Cytosol and Nucleus
Co-incubation of 6His-CM18-PTD4 and GFP-NLS in HeLa cells leads to GFP-NLS delivery to the cytosol after 30 sec followed by nuclear import 1 min later.
Translocation, energy-dependent macropinocytosis and clathrin-mediated endocytosis
In vitro