Back to search

Peptide record

TPDB62402

STR-H12R8 Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62402
STR-H12R8
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Stearylation
Sequence
HHHHHHHHHHHHRRRRRRRRRRRRRRR-NH2
Physicochemical Analysis
C162H266N96O28
ANDCEQGILKMFPSTWYV
R
4006.52
13.55
27
0
0
+16
23.67
-3.922
0.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
15
R
0
N
0
D
0
C
0
E
0
Q
0
G
12
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 15 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 12 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
27
C162H266N96O28
4006.52
13.55
+16
23.67
-3.922
Amidation
L
Cationic
Linear
Stearylation
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 cells, HeLa

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nucleic acid (GAPDH siRNA)
Cytoplasm
STR-H12R8 induced gene silencing with the knockdown efficiency of 31% at R/P 5 and 59% at R/P 10
Endocytosis
In vitro
CHHHHTTGGGCSCCC
Additional Detail Fields 1 fields
CHHHHTTGGGCSCCC