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Peptide record

TPDB62382

P3 Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB62382
P3
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Nonadecanoic acid (C19) on Lys
Sequence
HGLASTLTRWAHYNALIRAFGKRSAAAAAAK-NH2
Physicochemical Analysis
C147H234N48O38
DCEQMPV
A
3281.77
12.14
7
0
17
+5
-0.30
-0.016
82.58
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
6990
212.99
6
Residue Composition
number
10
A
3
R
1
N
0
D
0
C
0
E
0
Q
2
G
2
H
1
I
3
L
2
K
0
M
1
F
0
P
2
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 10 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 2 I: 1 L: 3 K: 2 M: 0 F: 1 P: 0 S: 2 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
31
C147H234N48O38
3281.77
12.14
+5
-0.30
-0.016
Amidation
Nonadecanoic acid (C19) on Lys
L
Amphiphilic
Linear
Free
N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Skbr3 Or MDA-MB-435 Cancer Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
Doxorubicin (Doxo)
Nucleus
Intensity increases by nearly a factor of 3 on going from NFs decorated with 1 μM to 5 μM of gH625.
In vitro
CGGGTGGGTSSHHHHHHTCSCCCCGGGGC
Additional Detail Fields 1 fields
CGGGTGGGTSSHHHHHHTCSCCCCGGGGC