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Peptide record

TPDB62380

gH625 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB62380
gH625
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Addition of Cysteine Chemical: Sulfocyanine 5-labeled SPOIN nanoparticles
Sequence
HGLASTLTRWAHYNALIRAFC
Physicochemical Analysis
C109H165N33O27S1
DEQKMPV
A
2401.77
9.90
4
0
11
+2
-2.45
0.224
93.33
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
6990
291.03
6
Residue Composition
number
4
A
2
R
1
N
0
D
1
C
0
E
0
Q
1
G
2
H
1
I
3
L
0
K
0
M
1
F
0
P
1
S
2
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 2 I: 1 L: 3 K: 0 M: 0 F: 1 P: 0 S: 1 T: 2 W: 1 Y: 1 V: 0
Chemical Descriptors
21
C109H165N33O27S1
2401.77
9.90
+2
-2.45
0.224
Addition of Cysteine
Sulfocyanine 5-labeled SPOIN nanoparticles
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Protein derived
siRNA-Atto390
Cytosol
2.5-fold higher uptake for CS-MSN after 4 h of incubation than S-MSN(without CPP)
Clathrin and caveolae mediated endocytosis
In vitro