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Peptide record

TPDB62379

APTstat3-9R Cell-penetrating Peptides standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB62379
APTstat3-9R
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 40-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC-labeled
Sequence
HGFQWPGSWTWENGKWTWKGAYQFLKGGGGSRRRRRRRRR
Physicochemical Analysis
C223H330N80O51
DCIMV
R
4947.58
12.71
13
1
10
+11
2.71
-1.795
12.25
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
28990
585.94
8
Residue Composition
number
1
A
9
R
1
N
0
D
0
C
1
E
2
Q
8
G
1
H
0
I
1
L
3
K
0
M
2
F
1
P
2
S
2
T
5
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 9 N: 1 D: 0 C: 0 E: 1 Q: 2 G: 8 H: 1 I: 0 L: 1 K: 3 M: 0 F: 2 P: 1 S: 2 T: 2 W: 5 Y: 1 V: 0
Chemical Descriptors
40
C223H330N80O51
4947.58
12.71
+11
2.71
-1.795
Free
FITC-labeled
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Nih3T3 , RAW264.7 , Mle12 And A549 Cell Lines

Assay & Model

Eight-week-old female C57BL/6 wild-type mice
Eight-week-old female C57BL/6 wild-type mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Chimeric
disc-shaped lipid nanoparticles(DLNPs)
FITC-labelled APTstat3-9R/DLNPs uptake increased by nearly 2.2 fold than naked APTstat3-9R
In vitro and in vivo
CCSSCTTCCSCCCSCCSCC
Additional Detail Fields 1 fields
CCSSCTTCCSCCCSCCSCC