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Peptide record

TPDB62367

GLP-1 Cell-penetrating Peptides standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB62367
GLP-1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 37-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
HDEFERHAEGTFTSDVSSYLEGQAAQGFIAWLVKGRG-NH2
Physicochemical Analysis
C182H267N51O58
NCMP
G
4097.43
4.79
5
6
14
-3
8.80
-0.519
58.11
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
6990
170.59
8
Residue Composition
number
4
A
2
R
0
N
2
D
0
C
4
E
2
Q
5
G
2
H
1
I
2
L
1
K
0
M
3
F
0
P
3
S
2
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 4 R: 2 N: 0 D: 2 C: 0 E: 4 Q: 2 G: 5 H: 2 I: 1 L: 2 K: 1 M: 0 F: 3 P: 0 S: 3 T: 2 W: 1 Y: 1 V: 2
Chemical Descriptors
37
C182H267N51O58
4097.43
4.79
-3
8.80
-0.519
Amidation
L
Anionic
Linear
Free
N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)O.C
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Anionic
Protein derived
FITC labelled
Internalization efficacy approximately 5- to 10-fold lower compared to PACAP38
In vitro
CCSSSSCCHHHHHHHHHHHHHHHHHSTTTTHHHHCCC
Additional Detail Fields 1 fields
CCSSSSCCHHHHHHHHHHHHHHHHHSTTTTHHHHCCC