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Peptide record

TPDB62366

hLF-His Cell-penetrating Peptides standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB62366
hLF-His
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 22-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Nanoparticle N-terminal: Acetylation
Sequence
Ac-HCFQWQHNMHHVHGPPVSCIHH-NH2
Physicochemical Analysis
C118H162N40O27S3
ARDELKTY
H
2669.02
7.45
7
0
6
+1
5.48
-0.709
44.09
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5625
210.75
6
Residue Composition
number
0
A
0
R
1
N
0
D
2
C
0
E
2
Q
1
G
7
H
1
I
0
L
0
K
1
M
1
F
2
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 2 E: 0 Q: 2 G: 1 H: 7 I: 1 L: 0 K: 0 M: 1 F: 1 P: 2 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
22
C118H162N40O27S3
2669.02
7.45
+1
5.48
-0.709
Amidation
Nanoparticle
L
Amphipathic
Linear
Acetylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mc3T3 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphipathic
Synthetic
(Cy5)-labeled eGFP mRNA
Cytosol
hLF-His, poor uptake was only slightly improved (∼25%) by oligomerization.
In vitro