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Peptide record

TPDB62358

T7 Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB62358
T7
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
B3Pred BBPpredict Peptipedia CPPsite3.0 TumorHoPe2.0
standard
No
A 7-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from B3Pred, BBPpredict, Peptipedia, and other sources, with an available 3D structural model.
Sequence
HAIYPRH
Physicochemical Analysis
C41H60N14O9
NDCEQGLKMFSTWV
H
893.02
9.88
3
0
3
+1
1.76
-1.071
70.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
166.85
1
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
7
C41H60N14O9
893.02
9.88
+1
1.76
-1.071
Evidence Records 4 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Leukemia

Source & Reference

TumorHoPe2.0
TumorHoPe2
Oncolytic T7 bacteriophage having cytokine gene and displaying homing peptide on capsid and its use for treating melanoma
2022
US 11384338 B2
US 11384338 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
6-week-old female Balb/C mice
Phage display library
T7 phage
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Transferrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Protease inhibitor:protease sensitive expression system, composition and methods for improving the therapeutic activity and specificity of proteins delivered by bacteria
2022
US 11219671 B1
US 11219671 B1

Other

Salmonella typhimurium
Phage display library
Ph.D-7 Phage Display
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Targeting

Source & Reference

TumorHoPe2.0
TumorHoPe2
2012
Yu-Lan Hu et al. Mol Pharm. 2012 Sep 4 9(9):2698-709.

Other

C57BL/6 mice
polyethylene glycol, TRAIL
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Brain tumor
Transferrin receptor (TfR)

Source & Reference

TumorHoPe2.0
TumorHoPe2
A simple self-assembly nanomicelle based on brain tumor-targeting peptide-mediated siRNA delivery for glioma immunotherapy via intranasal administration
2023
Tang L et al. Acta Biomater. 2023 Jan 1:155:521-537

Other

GL261 cell line (mouse glioblastoma cell), BV2 cell line (mouse microglia cell), 293T cell line (human renal epithelial cell line)
Tumor Bearing mice, Healthy mice
Synthetic
Cholestrol, siRNA
Additional Detail Fields 4 fields
polyethylene glycol, TRAIL Cholestrol, siRNA
GL261 cell line (mouse glioblastoma cell), BV2 cell line (mouse microglia cell), 293T cell line (human renal epithelial cell line)
6-week-old female Balb/C mice Salmonella typhimurium C57BL/6 mice Tumor Bearing mice, Healthy mice
T7 phage Ph.D-7 Phage Display