Back to search

Peptide record

TPDB62348

Tat (47-57) Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB62348
Tat (47-57)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Carries an extra glycine N-terminal: Carries an extra glycine and conjugation with fluores
Sequence
GYGRKKRRQRRRG
Physicochemical Analysis
C68H124N34O16
ANDCEHILMFPSTWV
R
1673.95
12.71
8
0
1
+8
6.51
-3.138
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
89.01
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
1
Q
3
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C68H124N34O16
1673.95
12.71
+8
6.51
-3.138
Carries an extra glycine
L
Cationic
Linear
Carries an extra glycine and conjugation with fluores
NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDCK cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Cytoplasmic and punctuated pattern (vesicles)
Condition dependent (not determined in this paper)
In vitro
CCCCSGGGGCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Calu-3 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Punctuated cytoplasmic (vesicles) as well as extracellular staining
Condition dependent (not determined in this paper)
In vitro
CCCCSGGGGCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

TR146 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Fluorophore (fluorescein)
Mainly extracellular staining
Condition dependent (not determined in this paper)
In vitro
CCCCSGGGGCCCC
Additional Detail Fields 1 fields
CCCCSGGGGCCCC