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Peptide record

TPDB62344

biotinyl-GM3BP Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB62344
biotinyl-GM3BP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Fmoc-Lys(biotin)−OH was linked with the C-terminus N-terminal: Biotinylation
Sequence
GWWYKGRARPVSAVAK-NH2
Physicochemical Analysis
C86H130N26O19
NDCEQHILMFT
A
1832.14
11.51
4
0
8
+4
-0.81
-0.581
55.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
681.72
2
Residue Composition
number
3
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
2
K
0
M
0
F
1
P
1
S
0
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 2 Y: 1 V: 2
Chemical Descriptors
16
C86H130N26O19
1832.14
11.51
+4
-0.81
-0.581
Amidation
Fmoc-Lys(biotin)−OH was linked with the C-terminus
L
Linear
Biotinylation
NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16, Cos7, And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
FITC-labeled Avidin
Around the Nucleus
In HeLa cells at 37 °C for 60 min, more than 80% of the GM3BP complex bound to the cell surface was internalized into cells
Caveolae-mediated and lipid raft-mediated endocytosis
In vitro
CBSCSSSBCCSSSSCC
Additional Detail Fields 1 fields
CBSCSSSBCCSSSSCC