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Peptide record

TPDB62332

MAAPC04 Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB62332
MAAPC04
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
GWRNQIRKGWQR
Physicochemical Analysis
C70H109N27O16
ADCEHLMFPSTYV
R
1584.81
12.71
4
0
3
+4
1.01
-2.167
32.50
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
694.09
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
2
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 2 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C70H109N27O16
1584.81
12.71
+4
1.01
-2.167
Free
L
Cationic
Linear
Free
NCC(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

E. Coli D31 And E. Coli Ml35 And Hrbcs

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
aminoglycoside tobramycin at N terminal
Displayed relatively low OM permeabilization at MICs (20 μM).
In vitro
CCSCCSCCCCCCC
Additional Detail Fields 1 fields
CCSCCSCCCCCCC