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Peptide record

TPDB62326

GR9 (PGN) Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB62326
GR9 (PGN)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: C6-labeled nanoparticles (PGN)
Sequence
GTFGFRRRRRRRRR
Physicochemical Analysis
C80H141N41O16
ANDCEQHILKMPSWYV
R
1933.26
13.30
9
0
2
+9
5.19
-2.600
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C80H141N41O16
1933.26
13.30
+9
5.19
-2.600
Free
C6-labeled nanoparticles (PGN)
L
Cationic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16F10 Cells

Assay & Model

Female C57BL/6 mice (20±2 g)
Female C57BL/6 mice (20±2 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Synthetic
Docetaxel (DTX) and Chloroquine (CQ)
Cytoplasm
Cellular uptake of PRN and PGN was 2.13-fold and 2.0-fold higher than that of PN, respectively, whereas ATG4B treatment reduced the fluorescence of intracellular PGN but had no effect on the fluorescence of PRN. PGN exhibited the highest fluorescence accumulation in the tumour site, which was 1.46- and 3.43-fold higher than that of PRN and PN, respectively
In vitro and in vivo