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Peptide record

TPDB62322

439A peptide Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB62322
439A peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
N-terminal: Conjugation with FITC
Sequence
GSPWGLQHHPPRT
Physicochemical Analysis
C66H96N22O17
ANDCEIKMFYV
P
1469.63
11.05
3
0
2
+1
2.54
-1.431
30.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
374.25
3
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
2
G
2
H
0
I
1
L
0
K
0
M
0
F
3
P
1
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 2 I: 0 L: 1 K: 0 M: 0 F: 0 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C66H96N22O17
1469.63
11.05
+1
2.54
-1.431
Free
L
Linear
Conjugation with FITC
NCC(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human carcinoma A431, HeLa and CHO

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Fluorophore (FITC)
On A431 cells, 10 fold lower than Tat but on HeLa
Caveolae-mediated and lipid raft-mediated endocytosis
In vitro
CCCCCCSCCCC
Additional Detail Fields 1 fields
CCCCCCSCCCC