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Peptide record

TPDB62316

TAT-E1A-WT Cell-penetrating Peptides standard
41 amino acids
Basic Information
3D PDB MODEL
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TPDB62316
TAT-E1A-WT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 41-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Conjugated with FLAG epitope
Sequence
GSHMGRKKRRQRRRPPQLEEPGQPLDELCKRPRDYKDDDDK
Physicochemical Analysis
C207H345N75O65S2
ANIFTWV
R
4988.60
10.19
14
9
5
+4
26.89
-2.346
28.54
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
29.87
6
Residue Composition
number
0
A
8
R
0
N
6
D
1
C
3
E
3
Q
3
G
1
H
0
I
3
L
5
K
1
M
0
F
5
P
1
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 0 D: 6 C: 1 E: 3 Q: 3 G: 3 H: 1 I: 0 L: 3 K: 5 M: 1 F: 0 P: 5 S: 1 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
41
C207H345N75O65S2
4988.60
10.19
+4
26.89
-2.346
Conjugated with FLAG epitope
L
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

H1299, A375, B16-F0

Assay & Model

C57BL/6 male mice (16–17 weeks and 30–35 g)
C57BL/6 male mice (16–17 weeks and 30–35 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
E1A peptides and FITC‐labeled
Nucleus
More Pep1‐fused peptide was detected in the nuclear fraction relative to the TAT‐fused peptide
In vitro and in vivo
CCCCCSSCGGGTCCCC
Additional Detail Fields 1 fields
CCCCCSSCGGGTCCCC