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Peptide record

TPDB62308

SRCRP2-11 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB62308
SRCRP2-11
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: FITC nanocomplexes
Sequence
GRVEVLYRGSW
Physicochemical Analysis
C60H92N18O16
ANDCQHIKMFPT
RGV
1321.50
9.87
2
1
5
+1
0.58
-0.373
88.18
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
528.94
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
1
E
0
Q
2
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
1
S
0
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 2
Chemical Descriptors
11
C60H92N18O16
1321.50
9.87
+1
0.58
-0.373
Free
FITC nanocomplexes
L
Cationic
Linear
Free
NCC(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human MCF7 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Cy3-tdTomato1 siRNA
Dose-dependent cellular uptake with the effect was maximal at peptide/siRNA molar ratios of 60:1 for FITC-SRCRP2-11 variant.
In vitro
CCCCCCCCCCCCCSCHHHHHHHTTCC
Additional Detail Fields 1 fields
CCCCCCCCCCCCCSCHHHHHHHTTCC