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Peptide record

TPDB62301

di-C-TAT Cell-penetrating Peptides standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB62301
di-C-TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 24-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: RhoUb
Sequence
GRRRQRRKKRKCCKRKKRRQRRRG
Physicochemical Analysis
C128H250N68O27S2
ANDEHILMFPSTWYV
R
3237.95
12.88
18
0
0
+18
16.36
-3.342
0.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.86
4
Residue Composition
number
0
A
12
R
0
N
0
D
2
C
0
E
2
Q
2
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 2 E: 0 Q: 2 G: 2 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C128H250N68O27S2
3237.95
12.88
+18
16.36
-3.342
Free
L
Cationic
Dimer
RhoUb
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Dimer L Cationic
Synthetic
Rhodamine-labelled Ub (RhoUb) protein
Cytoplasm and nucleus
Efficient delivery
Endocytosis
In vitro
CCCSCTTTSSCCCCC
Additional Detail Fields 1 fields
CCCSCTTTSSCCCCC