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Peptide record

TPDB62289

G-Penetratin Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB62289
G-Penetratin
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Glycine at the N-terminus
Sequence
GRQIKIWFQNRRMKWKK
Physicochemical Analysis
C106H171N35O21S1
ADCEHLPSTYV
K
2303.81
12.72
7
0
6
+7
2.30
-1.653
45.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
477.47
3
Residue Composition
number
0
A
3
R
1
N
0
D
0
C
0
E
2
Q
1
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 2 G: 1 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
17
C106H171N35O21S1
2303.81
12.72
+7
2.30
-1.653
Free
Glycine at the N-terminus
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Vero E6 Cells

Assay & Model

Dengue viruses (DENV serotypes 1–4), Zika virus (ZIKV, ATCC), Porcine Epidemic Diarrhea virus (PEDV) strain P70, G2 field isolate. and SARS-CoV-2 (Wuhan and B1.1.529 Omicron variant)
Dengue viruses (DENV serotypes 1–4), Zika virus (ZIKV, ATCC), Porcine Epidemic Diarrhea virus (PEDV) strain P70, G2 field isolate. and SARS-CoV-2 (Wuhan and B1.1.529 Omicron variant)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Protein derived
Human single-chain antibody (HuscFv)
Cytoplasm
The G-PEN-Hus-cFv34-6× His (green) was found in cytoplasm, indicating cell-penetrating ability
In vitro and in vivo